Seroprevalence of anti-Helicobacter pylori and anticytotoxin-associated gene A antigen antibodies according to ABO blood groups and rhesus status among hemodialysis patients

Correlation between Helicobacter pylori infection
and blood group typing has been widely evaluated in both
patients and healthy population. However, data addressing this
correlation in hemodialysis patients are scarce. The aim of this
study was to evaluate the prevalence of anti-Helicobacter pylori and
anticytotoxin-associated gene A (anti-Cag A) antigen antibodies
and their correlations with ABO blood groups and rhesus blood
group status in hemodialysis patients.
Materials and Methods. In a cross-sectional study, serum samples
of 151 hemodialysis patients were tested for anti-Helicobacter pylori
IgG antibody. Anti-Cag A antibody (IgG antibody) was tested in
Helicobacter pylori-positive patients. ABO blood groups typing and
rhesus status were tested by hemagglutination test.
Results. Prevalence of anti-Helicobacter pylori and anti-Cag A
antibodies in Helicobacter pylori-positive patients were 65.6% (99 of
151) and 25.3% (25 of 99), respectively. Prevalence of anti-Helicobacter
pylori and anti-Cag A antibodies were 69.1% and 36.8% in patients
with blood group A, 42.3% and 9.1% in blood group B, 75.0 % and
zero in blood group AB, 69.4% and 23.3% in blood group O, 59.0%
and 30.6% in rhesus-positive status and 89.7% and 11.5% in rhesusnegative
status, respectively. There was a significant correlation
between the presence of anti-Helicobacter pylori and anti-Cag A
antibodies and rhesus status, but no significant relation between
ABO blood groups and anti-Cag A antibodies were found.
Conclusions. Rhesus status may have an impact on the presence of
anti-Helicobacter pylori and anti-Cag A antibodies. More investigations
to address this correlation are necessary