Factor V Leiden G1691A and factor II G20210A point mutations and pregnancy in North-West of Iran.

Bagheri, M and Rad, I.A and Nanbakhsh, F (2011) Factor V Leiden G1691A and factor II G20210A point mutations and pregnancy in North-West of Iran. Archives of gynecology and obstetrics, 284 (5). pp. 1311-1315.

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Abstract

Purpose The roles of several hereditary predispositions for venous thromboembolism have been evaluated in women with habitual abortion. We studied the prevalence of FV Leiden G1691A and FII G20210A mutations in women with habitual abortion and healthy controls. Methods 60 unrelated fertile females, as controls, and 70 unrelated women with at least three consecutive pregnancy losses entered at the present study. MAS-PCR was carried out for detection of FV Leiden G1691A and FII G20210A mutations. Results FV Leiden G1691A mutation was not found in the studied cases and controls, that is, all of the cases and the controls had normal FV Leiden 1691GG genotype. FII 20210AA genotype was not found in any of patients or controls. 2.5% of alleles (3 out of 120 chromosomes) in controls and 15.714% of alleles (22 out of 140 chromosomes) in cases had FII 20210A mutation. The FII G20210A allele frequency was 0.157 in cases and 0.025 in controls. Regarding FII G20210A mutation, the distribution of GG, GA and AA genotypes were 48 (68.57%), 22 (31.43%) and 0 (0%) in the cases and 95 (95%), 5 (5%) and 0 (0%) in the controls, respectively. SigniWcant diVerences in both FII G20210A alleles and FII G20210A genotypes frequencies were observed in the cases versus the controls. Conclusion FII G20210A mutation is signiWcantly associated with habitual abortion.

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