Idiopathic hypercalciuria in children with vesico ureteral reflux and recurrent urinary tract infection

Our aim was to determine association of vesicoureteral reflux
(VUR) and idiopathic hypercalciuria in children with recurrent and single
episode of urinary tract infection (UTI).
Materials and Methods: The study group consisted of 45 children with
VUR and recurrent UTI, and 2 control groups: 45 normal healthy children
(control group 1) and 45 children with VUR and single episode of UTI
(control group 2). Idiopathic hypercalciuria was defined as urine calcium to
creatinine ratio more than 0.8 (mg/mg) in infants younger than 1 year old,
and more than 0.2 (mg/mg) in older children (without any detectable causes
for hypercalciuria).
Results: The study group consisted of 26 (57.8%) girls and 19 (42.2%) boys,
with the mean age of 41.14 ± 22.1 months. Nine (20%) subjects had
hypercalciuria. The control group 1 composed of 22 (48.9%) girls and 23 (51.1%)
boys, with the mean age of 43.98 ± 16.23 months. In this group, 6 subjects
(13.3%) with hypercalciuria were detected. The control group 2 composed
of 23 (51.1%) girls and 22 (48.9%) boys, with the mean age of 39.96 ± 24.2
months. In group 2, 7 subjects (15.6%) with hypercalciuria were detected.
Conclusion: Comparison between such results was not statistically
significant. Despite reports of different studies about accompanying of
hypercalciuria with recurrent UTI with or without anatomical abnormalities,
according to the present study, idiopathic hypercalciuria is not a major
contributing factor to recurrent UTI in children with VUR