Effect of Angiotensin II Type-1 Receptor Blockers on Stable Allograft Kidneys: Prospective Randomized Study

Nouri Majalan, N and Ghafari, A and Moghaddasi, S (2009) Effect of Angiotensin II Type-1 Receptor Blockers on Stable Allograft Kidneys: Prospective Randomized Study. Transplantation Proceedings, 41 (7). pp. 2832-2834.

[img]
Preview
Text
PIIS004113450900935X.pdf

Download (62kB) | Preview
Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Is assess the effects of angiotensin II type-I receptor blockers on outcomes in renal transplant recipients without proteinuria or posttransplantation erythrocytosis. Patients and Methods. Fifty renal transplant recipients (30 men and 20 women, with a mean [SD] age of 40 [13] years) were randomized into 2 groups of 25 patients each; 1 group was treated with losartan for 1 year, and the other was not (control group). Blood pressure and other biochemical parameters were measured at baseline and at 6 and 12 months posttransplantation. Results. After 1 year, the losartan group had significantly lower systolic blood pressure (113 [22] mm Hg vs 126 [18] mm Hg; P � .04) and hemoglobin concentration (12.8 [1.9] g/dL vs 14.5 [2.1] g/dL; P � .006) and significantly higher serum high-density lipoprotein cholesterol concentration (58 [22] mg/dL vs 47 [10] mg/dL; P � .03) compared with the control group; however the incidence of anemia did not differ (37% vs 20%; P � .20). In the losartan group, there were significant changes in hemoglobin concentration between baseline and 6 months (14.5 [1.6] g/dL vs 12.9 [1.49] g/dL; P � .001), but not between 6 and 12 months (12.9 [1.49] g/dL vs 12.8 [1.96] g/dL; P � .43). After 1 year, there were no significant between-group differences in diastolic hypertension, serum creatinine concentration, creatinine clearance, and serum potassium, low-density lipoprotein cholesterol, triglyceride, and uric acid concentrations. Conclusion. Losartan significantly increased high-density lipoprotein concentration and significantly decreased systolic hypertension. Although losartan decreased the hemoglobin concentration during the first 6 months, its effect did not progress with longer use. To determine the effect of losartan on renal function, additional studies with longer follow-up are needed.

Item Type: Article
Additional Information: cited By 2
Subjects: R Medicine > R Medicine (General)
Depositing User: Unnamed user with email gholipour.s@umsu.ac.ir
Date Deposited: 16 Aug 2017 04:25
Last Modified: 17 Feb 2019 06:12
URI: http://eprints.umsu.ac.ir/id/eprint/1287

Actions (login required)

View Item View Item