Key issues in F2-isoprostane analysis

Nourooz Zadeh, J (2008) Key issues in F2-isoprostane analysis. Biochemical Society Transactions, 36 (5). pp. 1060-1065.


Download (284kB) | Preview
Official URL:


A large body of evidence indicates that measurement of F2-isoprostanes, specific prostaglandin F2-like compounds derived from the non-enzymatic peroxidation of arachidonic acid, is a reliable biomarker of oxidant stress in the human body. Since the discovery of F2-isoprostanes in the early 1990s, a variety of analytical approaches has been introduced for the quantification of these novel compounds. The aim of the present review is to shed light on the available gas chromatographic–mass spectrometric assays for the measurement of plasma or urinary F2-isoprostanes and to highlight a number of issues which need to be addressed in order to implement F2-isoprostane measurement as a gold-standard biomarker of oxidative stress in biological samples

Item Type: Article
Additional Information: cited By 35
Uncontrolled Keywords: arachidonic acid, F2-isoprostane, lipid peroxidation, mass spectrometry (MS), oxidative stress.
Subjects: R Medicine > R Medicine (General)
Depositing User: Unnamed user with email
Date Deposited: 19 Aug 2017 04:11
Last Modified: 01 Sep 2019 06:59

Actions (login required)

View Item View Item