Melatonin: A pleiotropic molecule that modulates DNA damage response and repair pathways

Majidinia, M and Sadeghpour, A and Mehrzadi, S and Reiter, R.J and Khatami, N and Yousefi, B (2017) Melatonin: A pleiotropic molecule that modulates DNA damage response and repair pathways. Journal of Pineal Research.

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Abstract

DNA repair is responsible for maintaining the integrity of the genome. Perturbations in the DNA repair pathways have been identified in several human cancers. Thus, compounds targeting DNA damage response (DDR) hold great promise in cancer therapy. A great deal of effort, in pursuit of new anticancer drugs, has been devoted to understanding the basic mechanisms and functions of the cellular DNA repair machinery. Melatonin, a widely produced indoleamine in all organisms, is associated with a reduced risk of cancer and has multiple regulatory roles on the different aspects of the DDR and DNA repair. Herein, we have mainly discussed how defective components in different DNA repair machineries, including homologous recombination (HR), nonhomologous end-joining (NHEJ), base excision repair (BER), nucleotide excision repair (NER), and finally DNA mismatch repair (MMR), can contribute to the risk of cancer. Melatonin biosynthesis, mode of action, and antioxidant effects are reviewed along with the means by which the indoleamine regulates DDR at the transduction, mediation, and functional levels. Finally, we summarize recent studies that illustrate how melatonin can be combined with DNA-damaging agents to improve their efficacy in cancer therapy

Item Type: Article
Additional Information: cited By 1; Article in Press
Uncontrolled Keywords: cancer, chemotherapy, circadian rhythm, DNA, genome stability, pineal gland
Subjects: R Medicine > R Medicine (General)
Depositing User: Unnamed user with email gholipour.s@umsu.ac.ir
Date Deposited: 17 Jul 2017 05:38
Last Modified: 16 Apr 2019 05:54
URI: http://eprints.umsu.ac.ir/id/eprint/134

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