COMPARING THE EFFECT OF INTRACUFF ALKALINIZED LIDOCAINE AND LIDOCAINE ALONE ON POSTEXTUBATION COUGH IN LUMBAR LAMINECTOMY SURGERY

In general anesthesia, patients’ coughing during and after recovery is an important
clinical problem with a prevalence of 15% to 45%. This study aimed to evaluate the effects of alkalinized
lidocaine or lidocaine alone into the tracheal tube cuff on post-extubation cough in lumbar laminectomy
surgery with general anesthesia.
Materials & Methods: Ninety patients scheduled for lumbar laminectomy in prone position were
enrolled in this randomized double-blind prospective study. After tracheal intubation, the tracheal tube
cuff was filled with either an alkalinized 2% lidocaine solution or lidocaine alone or 0.9% saline. A
logistic regression comprising the two factors was used for analysis. The incidence of sore throat
reported by patients and cough 0, 10 and 30 minutes at recovery after extubation.
Results: Intracuff alkalinized 2% lidocaine was superior to lidocaine alone and saline in blunting
emergence coughing 10 and 30 minutes at recovery after extubation (P = 0.035- P= 0.005). The
incidence of sore throat was significantly lower in the alkalinized 2% lidocaine group at the recovery at
10 and 30 min after extubation(p = 0.001).
Conclusion: The present study showed that the intracuff alkalinized 2% lidocaine was superior to
lidocaine alone or saline in decreasing the incidence of emergence coughing and sore throat during the
recovery room after extubation.