ASSOCIATION STUDY OF THE RS6062314 POLYMORPHISM IN THE TNFRSF6B GENE IN MEN POPULATION WITH SPORADIC MULTIPLE SCLEROSIS IN KHUZESTAN PROVINCE

Zaidali, S and Safinejad, K and Galehdari, H (2017) ASSOCIATION STUDY OF THE RS6062314 POLYMORPHISM IN THE TNFRSF6B GENE IN MEN POPULATION WITH SPORADIC MULTIPLE SCLEROSIS IN KHUZESTAN PROVINCE. The Journal of Urmia University of Medical Sciences, 27 (10). pp. 856-862.

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Abstract

Multiple Sclerosis (MS) is an autoimmune, demyelinating and neurodegenerative disease of the central nervous system (CNS). The pathogenesis of this disease is still unknown, although there are evidences of environmental factors affecting subjects with genetic predisposition factors. TNFRSF6B protein in human is coded by the tnfrsf6b gene. One of the biological functions of TNFRSF6B is that it acts as death decoy and prevents cell death under certain circumstances. Some examples of studies have shown that rs6062314 (tnfrsf6b) polymorphism is associated with risk of MS. The aim of this study was to investigate the association of rs6062314 polymorphism in tnfrsf6b gene in men population with sporadic multiple sclerosis in Khuzestan province. Materials & Methods: The type of study was case-control and 100 unrelated subjects including 50 patients with low and moderate levels of MS (EDSS ≤ 3) and 50 healthy men were enrolled and molecular techniques were used; in addition, extraction of DNA, PCR, and direct sequencing were studied. Results: The genotype and allele frequencies of rs6062314 (tnfrsf6b) between MS patients and controls did not differ significantly (P-value=0.268 and P CC=1.0 and OR = 3.128, 95% CI = 0.61-15.89 for C allele). Conclusion: Our results showed that there was no association between rs6062314 (tnfrsf6b) SNP polymorphism and MS disease.

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