MANUFACTURE OF NANO-FIBERS ELECTROSPUN POLYAMIDOAMINES CONTAINING DOXORUBICIN

Doxorubicin sold under the trade names Adriamycin is an anticancer drug that
interferes with the growth and spread of cancer cells in the body. The purpose of this study was to
produce nano-fibers, polyamide amine (PAMAM) containing Doxorubicin drug using electrospinning
technique.
Materials & Methods: This cross-sectional study was conducted in the Faculty of Pharmacy in Tehran
University of Medical Sciences, from 2014 to 2015. In the this study, concentration of PAMAM in
ethanol, ratio of drug to polymer, Voltage and output current intensity as independent variables, and the
diameter of the fibers produced as the dependent variable were selected and studied. Then using the
SPSS software, equation of producing nano-fibers were evaluated and the polymer films containing drug
by SEM attention of the morphologic, and the diameter of the fibers and the FTIR were studied both
physically and chemically.
Results: According to the FT-IR of drug with the polymer After the electrospinning process, it was
revealed that neither of these two materials lost their properties during electrospinning, and no chemical
change was observed in their structure.
Conclusion: Provided that the solution concentration and the ratio of drug to polymer reduces, defective
fibers will be formed, and further reduction of these two parameters will lead to formation of micro and
nano particles