SERUM ANTIOXIDANT LEVEL IN PEMPHIGUS VULGARIS PATIENTS

Najafi, SH and Mohammadzadeh, M and Gholizadeh, N and Esmaeili, N and Ghasemi, F (2015) SERUM ANTIOXIDANT LEVEL IN PEMPHIGUS VULGARIS PATIENTS. The Journal of Urmia University of Medical Sciences, 26 (2). pp. 148-155.

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Abstract

Pemphigus comprises a group of autoimmune life threading diseases characterized by cutaneous and mucosal blistering. Pemphigus vulgaris (PV) is the most common and important variant. Recent reports have revealed the relatively high incidence of PV in Iran. The onset or aggravation of many human diseases is attributed to oxidative stress and it has been suggested as one of the several factors responsible for etiopathogenesis of pemphigus. The present study was performed to assess the association of serum level of antioxidant enzyme glutathione peroxidase (GPx) and total antioxidant (TAS) and SOD (superoxide desmotas) with pemphigus vulgaris. Materials & Methods: This case-control study evaluated patients referring to Razi Dermatology Hospital in Tehran, Iran from January 2011 to November 2012. Thirty patients with early diagnose of PV, who had never been under treatment were involved in this study as the case group and the control group consisted of 30 age- and sex-matched healthy people in the same center. The diagnosis of PV was confirmed by histopathology and direct immunofluorescence. Serum was collected from subjects for evaluation of glutathione peroxidase and total antioxidant levels and comparison with controls. GPX, TAS and SOD activity was analyzed by spectrophotometry method. Independent samples t-test was applied to compare the means of continuous variables. Statistical analysis was performed using SPSS software. P ≤ 0.001 was considered significant. Results: The mean serum level of glutathione peroxidase and total antioxidants was significantly lower in pemphigus patients. No statistically significant difference was observed between the groups in SOD levels of serum. Conclusion: The results of this study suggest that serum antioxidant level in patients with pemphigus has been changed and also showed that the change of TAS, GPX can have an important role in the Interactions of pemphigus

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