THE EFFECT OF PRP IN REPAIR OF FEMORAL ARTICULAR CARTILAGE NOTCHES ON EXPERIMENTALLY INDUCED OSTEOARTHRITIS RABBIT

Osteoartheritis is a degenerative joint disease characterized by gradual
degeneration of the joint cartilage, osteophyte formation, fibrillation and articular cartilage cracks.
Platelet rich plasma (PRP) contains growth factors and promotes regeneration of bones. Therefore the
purpose of this study was to investigate the effects of PRP on cartilage repair in the osteoarthritis
model in rabbits.
Materials &Methods: In this study, 25 white New Zealand rabbits of both sexes were used. The
anterior cruciate ligament of the right knee joint was resisted under general anesthesia. Eight weeks
following the operation, they were divided into five groups. The first group served as the control group
that received no treatment. The rest of rabbits received autogenic PRP in their joints. The rabbits were
euthanized and the joints were sampled for histopathologic study at 8 and 12 weeks post PRP
injection.
Results: The results proved that the autogenic PRP is rich of growth factors and repairs the
degenerated joints histology significantly compared to the control group and is useful in the treatment
of osteoarthritis.
Conclusion: PRP can be used to treat the joints affected by oateoarhteritis