ORAL VITAMIN E EFFECT ON ASPIRIN -INDUCED GASTRIC ULCERS BY ORAL AND PARENTERAL ADMINISTRATIONS IN RAT

Gastric ulcers are common worldwide that occur due to different agents such as
stress, cigarettes, non-steroid anti inflammatory drugs (NSAIDs) administration, and ethanol. NSAIDs
are responsible for 15- 25 % all gastric ulcers. This study was done to evaluate the effects of oral
vitamin E on oral and intra peritoneal (I.P) aspirin induced-gastric ulcers in rats.
Materials & Methods: This experimental (interventional) study was done on 30 rats weighing 200±20
gr which randomly were divided into 5 groups including the control group, group receiving 200 mg/kg
oral aspirin, group receiving 200 mg/kg aspirin as I.P, group receiving 100 mg/kg vitamin E pre oral
aspirin administration, and group receiving 100 mg/kg vitamin E pre I.P administration of aspirin
groups. Ulcers were evaluated by J. Score method (reported as J.Score±S.E.M.t student), and ANOVA
was used for data analysis.
Results: J. Score of IP administration of aspirin was 18.83±0.5 and then J. Score of oral
administration of aspirin was 16.1±0.6 , J. score of vitamin E ± I.P administration of aspirin was 8.6 ±
0.3 and finally J. score of vitamin E±oral administration of aspirin was 7.3±0.4. Significant decrease
was considered in ulcers in groups in which oral vitamin E administrated pre aspirin administration
(P< 0.05).
Conclusion: Vitamin E decreased aspirin induced gastric ulcers via antioxidant effects