INVESTIGATING THE EFFECT OF MULTI-WALLED CARBON NANOTUBES ON BRAIN WAVES IN RATS

Sadighi Alvandi, M and Ghamkhari Nejad, GH and Shahabi, P and Hosseinpour, M and Ghaderi Pakdel, F (2015) INVESTIGATING THE EFFECT OF MULTI-WALLED CARBON NANOTUBES ON BRAIN WAVES IN RATS. The Journal of Urmia University of Medical Sciences, 26 (8). pp. 681-689.

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Abstract

The changes of brain waves eventually sub-bands power incidence in the form of clinical protests. Regarding the use of multi-walled carbon nanotubes in neuroscience, the alpha/ theta power ratio is a reliable scale to measure the disorders associated with learning. The present study aimed to examine the effect of this substance examined on brain waves and investigated its possible effect on learning through analysis of brain waves sub-bands. Material & Methods: In this experimental study, 10 male Wistar rats (300-280 g, 4 to 6 months) were investigated in one group receiving nanotube. In order to record brain waves, electrodes were implanted in the frontal and the occipital cortex. Brain signals were recorded 15 minutes before and 15 minutes after injection of 1mg / kg carbon nanotube suspension. Results: After suspension injection, the power of gamma and theta sub-bands and the power ratio of theta to alpha sub-bands showed a significant reduction in the after injection intervals compared to baseline (control) (P <0/001). No significant change was observed in the alpha and beta sub-bands (P> 0/05). Conclusion: The results of this study showed that multi-walled carbon nanotubes reduce the power of gamma and theta sub-bands and the power ratio of theta to alpha sub-bands and possibly can lead to disorders associated with learning and memory

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