SURVEY OF CORRELATION BETWEEN SERUM CERULOPLASMIN LEVEL AND CORONARY ARTERY DISEASE

Over the last decade, cardiovascular disease (CVD) has become the single largest
cause of death worldwide including all developing regions. The coronary artery disease (CAD) is the
most lethal form of CVD. Ceruloplasmin is a ferroxidase enzyme with two paradoxically oxidative and
antioxidative performances. Some studies show that ceruloplasmin give rise to atherosclerosis by
oxidative effect on low density lipoprotein (LDL).
Materials & Methods: This study was done in Urmia Seyed-ol Shohada Hospital. The serum levels of
ceruloplasmin were measured in 43 consecutive CAD patients (more than 75% stenosis at least in one
coronary arteries by selective coronary angiography) and 43 consecutive control subjects (normal
epicardial coronary arteries by selective coronary angiography). Exclusion criteria were lymphoma,
pregnancy, oral contraceptive drugs, rheumatoid arthritis, Alzheimer's disease, heart failure
(LVEF<40%), diabetes mellitus, heavy smokers, obsessive disorders, schizophrenia, dyslipidemia, and
hypertension. CAD patients and normal group were matched for hypertension and dyslipidemia.
Results: There wasn’t significant statistical difference in serum ceruloplasmin level between CAD
patients (298±115mg/L) and control subjects (281±81mg/L).There wasn’t significant gender difference
in serum ceruloplasmin level.
Conclusion: The result of the present study doesn’t support the hypothesis that a high serum
ceruloplasmin level is a risk factor for coronary artery disease. If we exclude major CAD risk factors
and effective factors on serum ceruloplasmin level, it can be stated that a high serum ceruloplasmin level
is not an independent risk factor for atherosclerotic CAD