Zerehpoosh, M and Khadem Ansari, M.H and Kheradmand, F and Shirpoor, A.R (2016) EVALUATION THE EFFECT OF GINGER HYDRO-ALCOHOLIC EXTRACT ON THE HEART DYSFUNCTIONS INDUCED BY ALCHOHOL IN RAT. The Journal of Urmia University of Medical Sciences, 26 (12). pp. 1095-1101.
|
Text
10.pdf Download (522kB) | Preview |
Abstract
Chronic alcohol consumption is now recognized as a factor that enhances susceptibility to cardiovascular diseases through mechanisms that still are not completely cleared. The purpose of the present study was to investigate the effect of ginger extract on 8-hydroxy-2' - deoxyguanosine (8-OHdG) changes and as well as heart muscle cell proliferation induced by ethanol in the heart of rat. Materials & Methods: Twenty-four male Wistar rats were regimented to three equal sized groups: 1. Control, 2. ethanol (4.5 gr/kg BW by gavaj), 3. Ginger extract treated ethanolic groups (4.5 gr/kg ethanol along 50 mg of ginger extract). After 42 days, 8-OHdG and cell proliferation in heart tissue were measured. Results: The results showed a significant increasing in 8-OHdG amounts and heart muscle cell proliferation in ethanol group compared to the control group. Ginger extract administration along ethanol, reduced significantly 8-OHdG amounts and heart muscle cell proliferation compared to the ethanol group. Conclusion: These findings indicate that ginger extract significantly improves heart structural abnormality in ethanolic rats and that these effects can be associated with antioxidant and antiinflammatory properties of ginger extract.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Ginger, Ethanol, 8-OHdG, Proliferation |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 10 Oct 2017 08:25 |
| Last Modified: | 14 Apr 2019 04:41 |
| URI: | http://eprints.umsu.ac.ir/id/eprint/3163 |
Actions (login required)
 |
View Item |
