ASSOCIATION OF CHEMOKINE CCL2 GENE POLYMORPHISM WITH HENOCHE SCHONLEIN PURPURA DISEASE IN NORTH- WEST OF IRAN

Bonyadi, M and Mohammadian, T and Rafeey, M and Sadeghi Shabestari, M and Mortazavi, F (2015) ASSOCIATION OF CHEMOKINE CCL2 GENE POLYMORPHISM WITH HENOCHE SCHONLEIN PURPURA DISEASE IN NORTH- WEST OF IRAN. The Journal of Urmia University of Medical Sciences, 25 (11). pp. 998-1004.

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Abstract

Henoch–Schönlein purpura (HSP) is an autoinflammatory disease and systemic small vessel vasculitis that more frequently occurs in children. It is characterized by skin lesion such as Petechia and purpura, gasterointestinal involvement including abdominal pain and gastroint estinal bleeding and arthiritis. Studies have shown that HSP could be due to different infections and genetic factors. Based on the fact that cytokines have important role in this inflammatory disease, CCL2- a chemokine encoding gene- is studied in HSP patients from northwestern Iran. To achieve this goal molecular analysis of polymorphism located in promoter region of this gene is performed. Materials & Methods: This study was conducted on 40 HSP patients who were referred by immunology and allergy specialists to Genetic Center of Tabriz and after blood sampling and DNA extraction, molecular analysis with PCR-RFLP method was performed to genotype polymorphic region of promoter region of this gene. The results were compared to that of 50 ethnic-sex matched control healthy people. Results: Statistical analysis shows significant association of this polymorphism with development of Henoch–Schönlein purpura disease in this cohort. The frequency of TT and TC genotypes and T allele of CCL2 -C2518T gene polymorphism were significantly higher in HSP patients. Conclusion: CCL2 C-2518T gene polymorphisms were associated with susceptibility to HSP in Northwestern Iran.

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