TAQ 1B POLYMORPHISM IN CHOLESTEROL ESTER TRANSFER PROTEIN AND ITS ASSOCIATION WITH METABOLIC SYNDROME PARAMETERS

Metabolic Syndrome (MetS) is a potential threatening factor for cardiovascular
disorders and atherosclerosis which is accompanied by increase in plasma triglyceride, cholesterol,
low density lipoproteins (LDL-c), fasting blood sugar (FBS) and low high density lipoproteins (HDLc).

Cholesteryl ester transfer protein (CETP) catalysis transfer of lipids and phospholipids between
lipoproteins. CETP can have a significant role in balancing the quantity of plasma lipids and
lipoproteins. The present survey attempted to show the association of Taq1B polymorphisms in CETP
gene with metabolic syndrome parameters an Iranian population.
Materials &Methods: In order to identify the association between the Taq1B polymorphisms of this
gene and the lipid pattern of plasma and other parameters of MetS, the quantity of lipids in metabolic
syndrome subjects (N=247) and healthy individuals (N=247) were measured. The abundance of alleles
and genotypic distribution of the Taq1B polymorphisms were defined along with comparison between
two control and patient groups. Blood samples were collected followed by routine biochemical
analysis. DNA extraction was performed. Polymerase chain reaction-restriction fragment length
polymorphism was applied to identify Taq1B polymorphism. Statistical analyses were applied using
SPSS software.
Results: Lipid pattern of plasma and other parameters of MetS showed significant differences between
the patient and control groups. Also the abundance of alleles and genotypic distribution of
polymorphism showed a significant difference between two groups. Taq1B polymorphism was
accompanied with MetS.
Conclusion: The results confirm that in MetS patients, this genetic mutation in CEPT gene is
accompanied with change in lipid profile and other MetS parameters. Our study suggests the
promoting effect of Taq1B polymorphism in process of MetS disorder. We indicated this
polymorphism can increase occurrence of metabolic syndrome. Our results showed Taq1B
polymorphism is associated with some MetS associated variables in our population.