COMPARISON OF PETHIDINE AND DEXAMETHASONE IN PREVENTING POSTOPERATIVE SHIVERING

Entezariasl, M and Isazadehfar, KH (2013) COMPARISON OF PETHIDINE AND DEXAMETHASONE IN PREVENTING POSTOPERATIVE SHIVERING. The Journal of Urmia University of Medical Sciences, 24 (5). pp. 302-317.

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Abstract

Post-operative shivering is very common and it is usually followed by many problems such as an increase in oxygen consumption, blood pressure, intracranial and intraocular pressure, and post-operation pain. Therefore, it is very important to prevent shivering especially in the elderly and ischemic heart disease patients. The goal of this study was comparing the effect of Pethidine (Meperidine), Dexamethasone, and Placebo in prevention of shivering. Materials & Methods: This double blind clinical trial study was carried out on 120 patients who were candidates for surgery under general anesthesia.The patients were randomly divided into three groups including those who received placebo (a) Dexamethasone (b) and Pethidine (c). Induction and maintenance of anesthesia for all patients were similar. Central and peripheral temperature of patients was measured every 5 minute interval. After induction saline normal, Dexamethasone and Pethidine were respectively injected to groups a, b, and c. In recovery, all patients were controlled for visible shivering: The data were statistically analyzed by SPSS software and ANOVA and chi square tests. Results: There were no significant differences among three mentioned groups regarding of gender, age, duration of surgery, and recovery time. Nineteen cases (47.5%) in group a had post-operative shivering. Whereas, in group b only 4 cases (10%) had shivering and the difference between 2 groups was significant (P value = 0.001). Also in group c, 15 cases (37.5%) had shivering that the difference with placebo group was significant (P value = 0.08). Conclusion: The present study showed that pethidine and dexamethasone are effective drugs for preventing post-operative shivering in elective surgery. And the effect of dexamethasone in preventing the post-operative shivering is better than Pethidine. Dexamethasone can be administered after induction of anesthesia as an alternative to administration of Pethidine (as a common method of prevention and treatment of postoperative shivering) particularly in patients with hemodynamic instability.

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