COMPARING THE RESPONSE OF PLASMA TNFΑ، CRP, IL-6 AND LEUKOCYTE IN IMMATURE OVERWEIGHT AND NORMAL BOYS TO A SINGLE ACUTE EXERCISE

Obesity during childhood and adolescence in addition to acute symptoms plays a central role in a major component of the metabolic syndrome, the multiplex risk factor for type 2 diabetes and cardiovascular diseases. It has been established that cardiovascular risk factors in childhood and adolescence may predict risk of affection on cardiovascular disease in adults and exercise influence on these risk factors. The purpose of this study was to compare the response of plasma TNFα, CRP, IL-6 and leukocytes in immature overweight and normal boys to a single acute exercise

Materials & Methods: For this reason, 20 healthy male students (11-14 years-old) were selected randomly from volunteer subjects and divided into two groups (obese group, normal group). Then, after 5 min warming, every subject on ergometer cycle started cycling with 65-70% VO2 ax for 40 min. Blood samples were collected before, after, and one hour after exercise. Data were analyzed using independent T-test and analysis of variance with repeated measures (R-ANOVA) and post hoc LSD test.

Results: The data that resulted from comparing two groups showed that there was no significant difference between leukocyte subclass (p> 0.05) but the level of Crp, TNFα, and IL-6 in overweight compared to normal group were significantly higher in three times (p< 0.05).

Conclusion: A period of intense exercise 65 to 70 percent VO2 max increased white blood cell subgroups response and increased inflammatory factors such as IL-6 in obese and normal immature boys.