EVALUATION OF THE EFFECT OF SULPIRIDE AS AN ATYPICAL ANTIPSYCHOTIC DRUG ON THE SERUM LEVELS OF PROLACTIN, LH, FSH AND TESTOSTERONE IN ADULT MALE RATS

Dr. Rajab-Ali Saderkhanlou, Department of Basic Sciences, Histology and Embryology Section,
Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.
Prescription of the atypical antipsychotic drugs like as Sulpiride for the treatment of schizophrenic
patients was increased because of their less side effects. This study was aimed to evaluate the effect of
sulpiride on serum level of prolactin and sexual hormones.
Materials and method: Twenty three adult male mice were divided in three groups as test, control
sham and control. The test mice were received sulpiride solution, daily for 45 days IP. Mice in the
control sham were received the solvent only. Sample blood gathered and level of prolactin, LH, FSH
and testosterone were measured in the serum samples of all 3 groups and data was analyzed.
Results: A significant increase in serum prolactin levels was found in the treated mice which were
along with a significant decrease of LH, FSH and testosterone levels.
Conclusion: These findings indicate that sulpiride is able to induce prolactin reproductive
dysfunctions that by this induce and increase in proluctin leve; can control sexual hormons and
disorder normal functioning of the reproductivity