EVALUATION OF THE PROPHYLACTIC ANTIBIOTICS EFFECT ON THE LOW-RISK PATIENTS WHO CANDIDATE FOR ELECTIVE LAPAROSCOPIC CHOLECYSTECTOMY

Cholecystectomy is a most known procedure in patients with gallbladder disease such as
choleducolithiasis. This study aimed to study the effect of ampibactam prophylaxy
(ampicillin/sulbactam) on the low-risk patients who candidated for elective laparoscopic
cholecystectomy. Materials & Methods: This clinical double blind work study evaluating the elective
laparoscopic cholecystectomy in160 low-risk patients with choleducolithiasis that these patients can
consent informed and intentionally between 1389-90. Patients randomly divided in two groups
including group A as study group that received 3gr dose of ampibactam (Jaber-ebne-Hayyan Inc)
intravenously and group B as control group that received 10cc normal saline (N/S). The information
about age, sex, weight, body mass index (BMI), routine tests, hospital stay for all patients was
collected. The patients during hospitalization and within 30 days after surgery were followed for
incidence of infectious complications.
results: According to this study, 1 patient (2/1%) of the intervention group and 2 patients (5/2%) in
the control group were infected with the Fisher exact test showed no significant differences between
the two groups, and the incidence of infection (4/0 = P). In all three cases (9/1%) had an infection in
one patient (6/0%) from the intervention group and 2 patients (3/1%) of the control patients had a skin
wound infection (5 / 0 = P). (8/0 = P). The infection complications have seen in one pationet in control
group after 6 and in 2 pationts of study group after 5 day after cholecystectom. The mean duration of
hospitalization after cholecystectomy in 80 patients in the intervention group was