THE 4G/5G GENETIC VARIATION IN THE PROMOTER OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) GENE IN PATIENTS WITH RECURRENT MISCARRIAGE AND HEALTHY CONTROLS.

Bagheri, M and Nanbakhsh, F and Omrani, M and Abdi rad, I (2011) THE 4G/5G GENETIC VARIATION IN THE PROMOTER OF PLASMINOGEN ACTIVATOR INHIBITOR-1 (PAI-1) GENE IN PATIENTS WITH RECURRENT MISCARRIAGE AND HEALTHY CONTROLS. J Urmia Univ Med Sci, 22 (2). pp. 85-91.

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Abstract

Deletion/insertion of a single guanosine in the promoter of the plasminogen activator inhibitor-1 (PAI-1) gene, resulting in two alleles containing either 4 or 5 guanosines (G). Results of recent studies showed that presence of PAI-1 4G allele may increase the risk of human disease. The aim of present study was to determine the 4G/5G genetic variation in the promoter of PAI-1 gene in patients with recurrent miscarriage and healthy controls. Materials and Methods: Genotypes of 45 cases with recurrent miscarriage (at least 3 unexplained abortions) and 64 controls were determined by RFLP-PCR. Results: The findings of present study shows: Frequency (percent) of PAI-1 4G allele in cases and controls were 29(32.22%) and47(36.72%), respectively frequency (percent) of PAI-1 5G allele in cases and controls were 61(67.78%) and 81(63.28%), respectively. Frequency (percent) of PAI-1 5G/5G and 4G/4G was 16(35.56%) and 29(64.44%) in cases and 17(26.56%) and 47(73.44%) in controls, respectively. PAI-1 4G/4G genotype was not observed in studied groups. Statistical analysis showed that the frequencies of PAI-1 -675 4G/5G alleles and genotypes did not significantly differ between cases and controls. Conclusion: The findings of present study show that it is not possible to find any association between PAI-1 -675 4G allele and predisposition to recurrent miscarriage in tested population.

Item Type: Article
Uncontrolled Keywords: promoter of Plasminogen Activator Inhibitor-1 (PAI-1) gene, recurrent miscarriage, genetic variation, 4G, 5G
Subjects: R Medicine > R Medicine (General)
Depositing User: Unnamed user with email gholipour.s@umsu.ac.ir
Date Deposited: 30 Dec 2017 06:13
Last Modified: 25 Jun 2019 03:44
URI: http://eprints.umsu.ac.ir/id/eprint/3543

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