INTRODUCING AMNIOTIC MEMBRANE AS A NEW BIOMATERIAL IN CYSTOPLASTY.

Najafpour, A and Sabouri, A (2009) INTRODUCING AMNIOTIC MEMBRANE AS A NEW BIOMATERIAL IN CYSTOPLASTY. J Urmia Univ Med Sci., 20 (1). pp. 50-61.

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Abstract

Various congenital, malignant and benign acquired diseases may cause disorders in structure and normal function of bladder and therefore making its repair essential. Natural and synthetic alternative materials have been used to increase bladder volume. The aim of the present study was to change an incontinent high pressure low volume bladder into a continent low pressure high volume bladder and therefore providing a precious model for experimental medical studies. Materials & Methods : In the an experimental pilot study, using of fresh goat’s amniotic membrane (G.A.M.) as an organic material for bladder grafting in dogs, for the purpose of bladder augmentation were used in six healthy dogs, a piece of cranial wall of bladder, approximately 4-cm2 in diameter was resected and replaced with fresh G.A.M. For the purpose assessment of, microscopic pathologic parameters were studied. Results: Pathology findings were: the regeneration of transitional epithelium and proliferation of granulation tissue, No degenerative changes at the junction of the bladder and graft, was seen. Conclusion : The results indicate that fresh G.A.M act as a proper scaffold with least disadvantages, for repairing bladder defects in dogs.

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