A COMPARATIVE STUDY OF VAGINAL MISOPROSTOL PLUS OXYTOCIN AND OXYTOCIN ALONE IN THE PREPARATION AND INDUCTION OF LABOR IN THE THIRD TRIMESTER OF PREGNANCY

Induction of labor with an unfavorable cervix is one of the common reasons of
pharmacologic and non pharmacologic agents available for cervical ripening and labor induction. The
aim of this study was the assessment of cervical ripening with misoprostol in third trimester
termination of pregnancy.
Materials & Methods: This clinical trial study was conducted on 100 candidates for termination of
pregnancy in Kosar hospital with gestational age ≤28 weeks. The including criteria were nuliparity and
primiparity intact membrane single fetus bishop score≤5 reassuring FHR and cephalic presentation.
The excluding criteria were unexplained vaginal bleeding placental previa estimated fetal weight over
4kg any C.P.D previous uterine scar and medical contraindication of misoprostol. The patients were
divided into two groups with random allocation. In case group one dose of vaginal misoprostol
inserted posterior cul-de-sac. In control group induction of labor with low dose of oxytocin was done.
Result: The gestational age of mothers' parity initial bishop score mode of delivery staining of
meconium first and fifth Apgar score was similar in both groups. Interval induction until delivery in
misoprostol group was less than other group 442.7 ± 345 min Vs 635.9 ±371 min. About 22 women in
misoprostol group did not need oxytocin for induction and alone with single dose of misoprostol were
delivered (16womans 72/7%) NVD and (6womans 27/3%) C/S.
Conclusion: Further studies are recommended on the use of misoprostol on labor induction before the
end of term pregnancies with unfavorable cervix.