Hypertension and fluoride in drinking water: Case study from West Azerbaijan, Iran

Aghaei, M and Karimzadeh, S and Yaseri, M and Khorsandi, H and Zolfi, E and Mahvi, A.H (2015) Hypertension and fluoride in drinking water: Case study from West Azerbaijan, Iran. Fluoride, 48 (3). pp. 252-258.

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Abstract

Hypertension is a major public health challenge in Iran and its detection and control are vitally important to reduce the risk of myocardial infarction and cerebrovascular accident. Fluoride can be a risk factor for hypertension and, in this cross-sectional study, the effects on the prevalence of hypertension of high (3.94 mg F/L) and low (0.25 mg F/L) fluoride exposure via drinking water were investigated in two areas in West Azerbaijan province, Iran. The number of persons studied, aged 20–65 yr, was 897 (male: 453; female: 444) in the high fluoride area and 1981 (male: 945; female: 1036) in the low fluoride area. Cases were excluded who had aetiological factors known to contribute to hypertension, such as smoking, age >65 yr, a family history of hypertension, lack of mobility, cardiovascular disease, and obesity. In the high fluoride area, compared to the low fluoride area, hypertension, without known aetiological factors, was increased (p<0.05) in females aged 50–59 yr and decreased (p<0.05) in the combined group of males and females aged 40–49 yr. Because of the varying results of the studies in this topic, further research is recommended.

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