STUDY OF IVIG TREATMENT WITH PHOTOTHERAPY AND PHOTOTHERAPY IN DECREASING OF INDIRECT BILIROBIN IN BABIES WITH ABO AND RH HEMOLOTIC DISEASS

Intravenous immune globulin (IVIG) treatment in isoimmune hemolytic jaundice has
been shown to be effective. In this study two dose administration method of therapy was researched.
Materials & Methods: In this study, the effect of two doses IVIG therapy was investigated in 56
babies who had ABO and Rh hemolytic disease. At admission all cases serum level of bilirubin was in
range of phototherapy treatment. Patients were divided into two groups. Groups Ι (cases=28) received
two dose IVIG treatment plus phototherapy, group ΙΙ(control=28) received just phototherapy.
Exchange transfusion rate, reduction of serum bilirubin levels and duration of phototherapy were
compared between two groups.
Results: Mean ages, weight, bilirubin level, hemoglobulin, hematocrite, reticulocyte, hospitalization
days, exchange transfusion and reduction of bilirubin level were 2.35±1.25, 3.07±2.5*days (p=0.191),
3026±305, 3152 ±295* grams (p=0.1), 17.62±2.38, 16.65±2.55* mg/dc (p=0.147), 12.42 ± 1.21,
12.35±1.9* gram/dc (p=0.68), 36.78±5.7 percent, 36.58±4.5* (p=0.88), 5.6±2*, 4.5±2.7percent
(p=0.109), 2.8±1.3*, 3.6±2.5 days (p=0.033), 0.0, 2.0 (p=0.002)and 7.9±0.46, 1.39±0.27mg/dl
(p=0.021) for control and case group respectively*.
Conclusion: in spite of that baseline characteristics were similar in two groups there was significant
difference at outcome of index. Regard to results of this study it was concluded that two doses IVIG
treatment reduces the need of exchange transfusion and lowers serum bilirubin levels in neonatal
isoimmune hemolytic jaundice.