EVALUATING THE RATE OF IMMUNE RESPONSE FOR HEPATITIS B VACCINE IN HIGH RISK PERSONEL

Hepatitis B virus(HBV) is a major cause of the leading causes of hepatocellular
carcinoma acute and chronic hepatitis. There is no specific treatment so, prevention with vaccination
has been the best aim in managing viral hepatitis B.Since health workers areat high risk care 3-6 times
more than other persons, fllowing measures must be recommended. observance of standard
precautions, identification of high risk or infected personel, active or passive immunization, serologic
tests for titer of antibody and other measures for protection of persones.
Methods and Materials: In this descriptive analytic study, 100 persones of Alavi eye center in Tabriz,
referred to central laboratory for titrating hepatitis B antibody. Informed consent was obtaind from all
subjects .After blood sampling, serum HBsAg and HBsAb titrated. Based on antibody titer, persons
were divided to three groups: immune, partial immune and non immune. All information were
tabulated in computer and analyzed with SPSS (11 edition) statistical software.
Findings: Mean age of 100 participated persons was 37 years. Out of 100, 38% were male and 62%
female and 12 % were smoker, 88%nonsmoker. Among 11% of persons, antibody titer was lower than
10 (non immune), 14 % between 10-100 (partial immune), and 75 % more than 100 (immune). 80%
were nurses, 4 %labratory personnel, 6 % physicians and para medical personnel and 10 % service
staff. According to this study antibody titer had meaning full relationship with sex, smoking, duration
of vaccination and regular vaccination.
Conclusion: Since HBV are seen in health worker more than other persons so, identification of
non immune personnel is necessary. For prevention of hepatitis B repeatition of vaccination is
recommended, because immunity decreases with duration of time.