Immunohistochemical study of C-kit expression in subtypes of renal cell carcinoma

Noroozinia, F and Dindarian, S and Abbasi, F and Mohammadi, S and Bagheri, M and Meisami, F and Mohammadi, H (2018) Immunohistochemical study of C-kit expression in subtypes of renal cell carcinoma. Turk J Urol, 44 (1). pp. 31-35.

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Abstract

Renal cell carcinomas (RCCs) include about 2% of adult neoplasms and 90-95% of all renal tumors. Mostly, it is possible to distinguish RCC subtypes using hematoxylin-eosin staining. However, overlapping morphologic features cause some diffculties in making a precise diagnosis. In order to render an accurate diagnosis, additional methods such as immunohistochemical staining for c-kit have been recommended. In this study, we aimed to investigate c-kit gene expression in various subtypes of RCC. Material and methods: We reviewed 65 diagnosed RCC cases. Formalin- fxed, paraffn- embedded specimens were available for the cases. The expression of c-kit was evaluated using immunohistochemistry. The correlation between c-kit expression and clinicopathological parameters including patients’ age and gender in addition to grade, stage, and size of the tumor were investigated. Results: Six cases of 39 clear cell types (15.4%), 8 of 13 papillary types (61.5%), 11 of 12 chromophobe types (91.7%), and no sarcomatoid type were positive for c-kit expression. Based on chi-square test results, there was a signifcant relationship between RCC subtypes and c-kit expression (p=0.001). There was no signifcant correlation between age, sex, grade, stage, and size of the tumor and c-kit expression. Conclusion: The expression of c-kit in RCC may have diagnostic signifcance in subtypes of RCC especially papillary and chromophobe subtypes of RCC

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