Immunohistochemical study of C-kit expression in subtypes of renal cell carcinoma

Norouzinia, Farahnaz and Dindarian, Sina and Abbasi, Fariba and Mohammadi, Sedra and Bagheri, Mahdi and Meisami, Farid and Mohammadi, Hozan (2018) Immunohistochemical study of C-kit expression in subtypes of renal cell carcinoma. Turk J Urol, 44 (1). pp. 31-35.


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Renal cell carcinomas (RCCs) include about 2% of adult neoplasms and 90-95% of all renal tumors. Mostly, it is possible to distinguish RCC subtypes using hematoxylin-eosin staining. However, overlapping morphologic features cause some diffculties in making a precise diagnosis. In order to render an accurate diagnosis, additional methods such as immunohistochemical staining for c-kit have been recommended. In this study, we aimed to investigate c-kit gene expression in various subtypes of RCC. Material and methods: We reviewed 65 diagnosed RCC cases. Formalin- fxed, paraffn- embedded specimens were available for the cases. The expression of c-kit was evaluated using immunohistochemistry. The correlation between c-kit expression and clinicopathological parameters including patients’ age and gender in addition to grade, stage, and size of the tumor were investigated. Results: Six cases of 39 clear cell types (15.4%), 8 of 13 papillary types (61.5%), 11 of 12 chromophobe types (91.7%), and no sarcomatoid type were positive for c-kit expression. Based on chi-square test results, there was a signifcant relationship between RCC subtypes and c-kit expression (p=0.001). There was no signifcant correlation between age, sex, grade, stage, and size of the tumor and c-kit expression. Conclusion: The expression of c-kit in RCC may have diagnostic signifcance in subtypes of RCC especially papillary and chromophobe subtypes of RCC

Item Type: Article
Uncontrolled Keywords: C-kit; H&E staining; KIT; renal cell carcinoma
Subjects: R Medicine > R Medicine (General)
Depositing User: Unnamed user with email
Date Deposited: 25 Apr 2018 05:05
Last Modified: 25 Apr 2018 05:05

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