Shirpoor, A.R and Rasmi, Y and Hosseini Gharalari, F and Heshmati, E (2017) Ginger extract attenuates ethanol–induced pulmonary histological changes and oxidative stress in rats. The Journal of Biomedical Research. pp. 1-7.
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Abstract
Chronic ethanol consumption is associated with changes in the function and structure of the lungs. The aim of this study was to investigate the effect of chronic ethanol exposure on the lungs and whether ginger extract mitigated pulmonary abnormalities induced by ethanol in rats. Male Wistar rats were divided into the control group, the ethanol group, and the ethanol plus ginger extract group. Six weeks of ginger extract treatment increased the proliferation of lung cells, and induced fibrosis, inflammation and leukocyte infiltration. A significant rise in the level of 8– hydroxydeoxyguanosine, NADPH oxidase, and oxidized low–density lipoprotein was also observed. Ginger extract significantly ameliorated the above changes. These findings indicate that ethanol induces abnormalities in the lungs by oxidative DNA damage and oxidative stress, and that these effects can be alleviated by ginger, which may function as an antioxidant and anti–inflammatory agent.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ethanol, lung, oxidative stress, DNA damage, rat, fibrosis, ginger |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 29 Apr 2018 06:05 |
| Last Modified: | 31 Mar 2019 06:50 |
| URI: | http://eprints.umsu.ac.ir/id/eprint/4778 |
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