The effect of Cystatin C in the Prevention of Transplantation Rejection and the Cause of Kidney Failure

Serum cystatin c is not routinely used in the evaluation of renal function and
this may be due to high costs, lack of adequate studies on precision, lack of accessibility and
reliability. More kidney transplanted patients before creatinine increasing encounter with
decreased performance and go toward rejection without certain actions. This study was aimed
to evaluate the effect of cystatin C in the prevention of transplantation rejection. Methods: In
this prospective study, cystatin c and GFR of 49 kidney transplanted patients in the third, eighth
and fourteenth day were evaluated. The correlation of cystatin C and transplant rejection was
investigated with Spearman correlation. Results: In our study, there were statistically signifcant
relationship between serum level of cystatin c in third, eighth and fourteenth day with transplant
rejection. Cystatin C indicated that was a more sensitive indicator compared with creatinine on
the fourteenth day in the event of loss of GFR below than 60. Conclusion: Serum cystatin c
as a valuable marker can be an effective predictor marker of renal function decreasing beside
creatinine. Due to high cost of measuring kits of serum cystatin c, this marker can be used in
high-risk patients with possibility of rejection.