ASSOCIATION OF SERUM PROLACTIN CONCENTRATIONS WITH RENAL FAILURE IN DIABETIC PATIENTS

Diabetes is one of the causes of end-stage renal disease, so that
about 70% of all diabetic patients have nephropathy. Prolactin is a hormone that is
affected by diabetes but the interaction between diabetes and prolactin has not been
understood properly. This study aimed to evaluate the relationship between changes in
serum prolactin levels in diabetic patients with renal failure. Material and methods: In
this study 223 individuals were participated and after assessment of inclusion/ exclusion
criteria 189 individuals were evaluated. Finally, the individuals were divided into three
groups: Control (C), Diabetic (D), and Diabetic Nephropathy (DN). Blood samples were
collected between 8.00 a.m. and 12.00 a.m. for measurement of prolactin levels and
biochemical analysis. Results: The results showed that sodium, potassium, urea,
creatinine and prolactin significantly increased in DN group compared to control
individuals (P< 0.001). The prolactin levels were significantly decreased in the group of
patients with diabetes (P< 0.001). Conclusion: The results of the current study indicated
that serum prolactin level decreased in diabetes while it increased in diabetic
nephropathy