The Effect of Body Mass Index on Patient and Graft Survival Rate in Kidney Transplanted Patients in Iran

Ghelichi Ghojogh, M and Taghizadeh Afshari, A and Salarilak, S and Mohammadi Fallah, M.R and Khalkhali, H.R and Makhdoomi, K (2017) The Effect of Body Mass Index on Patient and Graft Survival Rate in Kidney Transplanted Patients in Iran. Nephro-Urol Mon, 9 (4). pp. 1-6.

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Abstract

The number of patients with overweight and obesity requiring renal transplant in the past 2 decades increased considerably. Objectives: The current study aimed at evaluating the effect of body mass index (BMI) on graft and patients survival rate. Design: In the current retrospective, cross sectional study, transplant recipients were divided into 3 groups based on their BMI: group 1(BMI < 18.5 kg/m2), group 2(BMI = 18.5 to 25 kg/m2), and group 3(BMI > 25 kg/m2). Kaplan-Meier formulawas used to calculate the patient survival rate, log-rank test to compare the survival curves, analysis of variance(ANOVA) to compare continuous variables, and the Chi-square test to compare the classified data. Statistical analysis was performed by SPSS version 19. P values ≤ 0.05 were considered significant. Results: The 5-year follow-up on patients’ survival rate in groups 1, 2, and 3 was 91% ± 0.03%, 91% ± 0.01%, and 80 ± 0.03%, respectively. Also, the 5-year graft survival rate in groups 1, 2, and 3 was 90% ± 0.02%, 85% ± 0.02%, and 76 ± 0.03%, respectively. There were significant differences between BMI status and gender of the recipients (P value = 0.003) and those of the donors (P value = 0.003), type of kidney in donors (P value = 0.001), type of dialysis in recipient (P value = 0.001), history of type 2 diabetes mellitus in recipient (P value = 0.001), recipient age (P value = 0.001), duration of hospitalization (P = 0.026), cholesterol levels after 1 year (P value = 0.001), and BMI status of the recipient. Conclusions: The results also indicated that the graft survival rate of the recipients was not statistically different in terms of BMI; thus, the results suggested that to allow of counting in patients included overweight and obesity kidney transplantation as appropriate action treatment

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