EVALUATION OF THE RELATIONSHIP BETWEEN SERUM URIC ACID LEVEL AND OUTCOME OF PATIENTS WITH ACUTE EXACERBATION OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Tissue hypoxia induces the degradation of adenosine triphosphate, resulting in
the production of uric acid (UA). Elevation of serum uric acid levels has been observed in hypoxic
subjects, including patients with chronic obstructive pulmonary disease. Patients with chronic
obstructive pulmonary disease (COPD) have been reported to have high serum levels of uric acid
compared with control subjects. In this study, we examined the relationship between spirometric
measures and serum uric acid levels in different staging of COPD and outcome patients
Materials & Methods: A total of 79 patients with chronic obstructive pulmonary disease with age range
of 38-83 years were enrolled. 51 of the patients (64.6%) were men and 28 patients (35.4%) were
female.Subjects aged 38 years or older (n = 79), who admitted in Imam Khomeini Hospital in Urmia
with chronic obstructive pulmonary exacerbation without comorbid conditions. The uric acid level was
measured from the morning blood sample of the patients and during the hospitalization, the patients
were evaluated for serum uric acid levels and evaluated outcomes including recovery and discharge,
ventilator connection, transfer to ICU and death. The correlation between serum uric acid and changes
in FEV1 was also investigated.
Results: The results of data analysis showed that the mean age of patients in the study was 62.94 ±15.06
years, and the mean uric acid and FEV1 in patients were 5.16± 2.50 mg / dl and 0.74 ±0.19 respectively.
Significant differences between the level of serum uric acid in patients who have recovered and have
been discharged (patients without adverse events) and patients with at least one of the cases (need to
Vetilator, need for ICU or death) were not observed. There was no statistically significant relationship
between severity of disease (FEV1 level) and serum uric acid level.
Conclusion: Serum uric acid levels have no predictive value for predicting the outcome of hospitalized
patients with acute exacerbation of chronic obstructive pulmonary disease. Also, the serum level of uric
acid is not a reliable marker for determining the severity of chronic obstructive pulmonary disease