Evaluation of Serum Iron, Zinc and Their Relationships with Glycemic Control Status in Iranian Elderly Women with Type 1 Diabetes Mellitus

Mohammadian, M and Hassas, M.R and Toofani Milani, A and Rostaminas, S and Roshaniasl, E and Rashidi, S and Nemati, M and Mokarizadeh, N and Javandust, F and Fathi younesi, F (2015) Evaluation of Serum Iron, Zinc and Their Relationships with Glycemic Control Status in Iranian Elderly Women with Type 1 Diabetes Mellitus. Journal of Pharmacy and Pharmacology, 3. pp. 411-416.

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Abstract

It seems that defects on micro-minerals levels have an etiologic role involved in type 1 diabetes mellitus pathogenicity. The aim of our study were to evaluate the serum levels of zinc and iron and investigate their possible relationship between these biochemical parameters with demographic conditions and glycemic control in patients with type 1 diabetes mellitus disorder. In this case-control based study , 68 female with type 1 diabetes mellitus with a mean age of 52.2 ± 2 as case group and 122 healthy women as a control group with a mean age of 49/4 ± 3/2 were investigated .for biochemical analysis ,10 mL fasting venous blood sample were obtained from each subjects. FBS (fasting blood glucose), fructosamine (glycemic control parameter) were determined (spectrophotometry method, (pars azmoon, Iran), nitroblue tetrazoline method respectively).serum zinc level with colorimetric method (Biorex-UK) and serum iron with photometric method (pars azmoon, Iran) were determined. Statistical analysis using SPSS software performed. Significant levels considered as P < 0.05. According to this study there is statistically significant difference between serum levels of iron and zinc in patients with type 1 diabetes compared to controls .indeed serum level of iron and zinc had lower level in patient group toward controls. In patients group, there are a positive correlation between age and decreased level of serum zinc (P < 0.05). Also there was a significant negative correlation between the glycemic control status and serum zinc. Other studied parameters concluded BMI (body mass index), Weight and height have not significant difference between groups. The decrease in serum iron and zinc level in women with type 1 diabetes may be related to low dietary intake or increased excretion of micro minerals or the presence of confounding factors that require more extensive intervention studies to confirm it

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