The Effect of Two Different Doses of Cuminum Cyminum Extract on Serum Glycemic Indices and Inflammatory Factors in Patients with Diabetes Type II: A Randomized Double-Blind Controlled Clinical Trial

Type 2 diabetes is a metabolic disorder considered as one of the
most common chronic diseases in many countries, including Iran. One of the reducing factors
in insulin sensitivity is increased serum levels of inflammatory factors like hsCRP and TNF-
α. On the other hand, in recent years, Cuminum Cyminum is known as one of the potent herbs
in the treatment of diabetes type 2 in animal studies. The aim of this study was to evaluate the
effect of two doses of 50 and 100 mg of Cuminum Cyminum extract on glycemic indices and
indicators of inflammation in human subjects with type 2 diabetes mellitus.
Methods: This study is a double blind randomized clinical trial performed in Urmia city on
2015. Samples were selected based on inclusion criteria and randomly divided into 3 groups:
two groups receiving Cuminum Cyminum extract of 50 and 100 mg per day and the control
(placebo) group. Before and 8 weeks after intervention, fasting blood sugar, serum insulin and
inflammatory profile of hsCRP and TNF-α were measured. Data were analyzed by SPSS and
the effect of supplementation was studied.
Results: The mean age of the all participants was 47.33±6.36. Results showed that the mean
fasting blood sugar (FBS), glycosylated hemoglobin (HbA1c), and serum insulin reduced
significantly in the both groups receiving Cuminum extract of 50 and 100 mg(p<0.01)., but
increased in the placebo group. Average hsCRP and TNF-α levels have shown significant
reduction at the beginning and end of the study in either group receiving 50 and 100 mg of
supplementation (p<0.01).
Conclusion: This study indicates that short-term daily supplementation of Cuminum
Cyminum extract at the doses of 50 or 100mg in patients with type 2 diabetes during 8 weeks
may act to reduce the serum levels of insulin, blood glucose, glycosylated hemoglobin and
hsCRP and TNF-α levels, and also may be fruitful for control of this disease.