Urinary tract infections among kidney transplant patients due to extended-spectrum beta-lactamase-producing bacteria

Kashef Nejad, M and Sharif, Y and Hosseini Jazani, N (2017) Urinary tract infections among kidney transplant patients due to extended-spectrum beta-lactamase-producing bacteria. Microbial Pathogenesis. pp. 1-4.

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Abstract

CORRE At present, in patients with end stage of renal failure, kidney trans lantation is a selective therapeutic strategy due to better rates of life articipation [1,2]. However, receiving of immunosuppressant med cation encounter kidney transplant patients (KTPs) at increased risk f cancer, infection, diabetes and cardiovascular disease [3]. The pres nce of infections greatly influences the success of kidney transplan ation since they cause higher morbidity and mortality and also in rease the length and expenditure of hospitalization [4]. Of the in ections, urinary tract infection (UTI) has been considered a common roblem, occurring in 60% of KTPs during the first year post-trans lant [5]. Some studies reported an increased incidence of bacter al infection with multiple antibiotic resistances among transplant pa ients [6]. Of the bacteria, extended spectrum beta-lactamases (ES BLs) producing gram negative bacteria most commonly Escherichia oli and Klebsiella spp have the ability to hydrolyze and cause resis ance to oxyiminocephalosporins and monobactams [7,8]. Recently, he prevalence of CTX-M-type ESBLs (bla CTX-M) has been increased nd such ESBLs may cause resistance to some unrelated classes of an ibiotics [9]. CTX-M enzymes are currently divided into five clusters n the basis of amino acid sequence, including: CTX-M-1, CTX-M-2, CTX-M-8, CTX-M-9 and CTX-M-25 [10]. Since the infections can ffect renal transplantation outcomes and little information were avail ble regarding the frequency of ESBLs among KTPs, this study was esigned to investigate the susceptibility pattern, frequency of ESBLs nd bla CTX-M among the isolated E. coli and Klebsiella spp from urine pecimens of KTPs using phenotypic and molecular methods.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Depositing User: Unnamed user with email gholipour.s@umsu.ac.ir
Date Deposited: 04 Aug 2018 03:57
Last Modified: 31 Mar 2019 07:25
URI: http://eprints.umsu.ac.ir/id/eprint/4974

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