Tayefi Nasrabadi, H and Abedelahi, A and Naghibi, M and Mohammadnejad, D (2015) Cetrorelix preserves follicular viability in Cyclophosphamid-induced ovarian toxicity. International Journal of Research in Applied and Basic Medical Sciences, 1 (1). pp. 56-60.
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Abstract
Anticancer drugs are known to have great impact on spermatogenesis process and germinal epithelium. The present study is to investigate the preventive effect of Cetrorelix (GnRH antagonist) on Cyclophosphamide- induced spermatogenic defect. Methods and Materials: Fifty adult female mice aging 6-8 weeks (30±4 gr) were divided into 3 groups as: Control, Experimental 1 and Experimental 2. The animals in Experimental 1 group received Cyclophosphamide (2.5 mg/kg, ip) for 5 days and in Experimental 2 group received Cetrorelix (0.25 mg/kg, ip) one week before Cyclophosphamide treatment and continued for 3 weeks. The mice in all groups were sacrificed 35 days after the last injection. Ovarian follicles were isolated mechanically and the viability was studied by trypan blue staining. Results: Ovarian follicles of animals in Experimental 2group, retained higher percentage of normal morphology (P<0.001) than which in Experimental 1 group and their condition were similar to control group. Conclusion: These results indicate that the Cetrorelix administration before cancer treatment may protect ovarian tissue against side effects of cisplatin
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Ovarian follicles, Viability, GnRH antagonist, Cetrorelix |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 14 Aug 2018 06:36 |
| Last Modified: | 06 Jul 2019 04:43 |
| URI: | http://eprints.umsu.ac.ir/id/eprint/4991 |
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