Lack of Association Between Lipid and Lipoprotein Profile and Menopause Status in Women with Cardiac Syndrome X

Cardiac syndrome X (CSX) or angina pectoris is characterized by positive findings on exercise
electrocardiography and normal results on coronary angiography). It frequently occurs in
menopausal women. On the other hand, studies indicated that menopause is associated with
alteration in lipid profile and increased risk of cardiovascular diseases. Therefore, this study
aimed to determine the possible influence of menopause on lipid and lipoprotein profile in
women with CSX. Fifty women with CSX (mean age: 52.4±7.65 years) and 50 healthy women
as control (50.0±5.62 years) were studied. CSX and control groups were divided as pre- and
post-menopause subgroups. The plasma lipid and lipoprotein profile of subjects was estimated
colorimetrically. The total cholesterol (TC), triglyceride (TG), lipoprotein A(LP[a]), low density
lipoprotein (LDL), high density lipoprotein (HDL), apoprotein A1(APOA1), apoprotein B
(APOB) were significantly higher among those in the CSX group than those of the control group.
(TC: 158.2±5.7 vs. 114.5±5.1mg/dl; P=0.001, (TG: 152.1±11.4 vs. 105.9±8.9mg/dl; P=0.002, LP[a]:
44.2±7.9 vs. 22.2±4.3mg/dl; P=0.017, LDL: 88.9±3.7 vs. 66.1±23.4mg/dl; P=0.001, HDL: 36±1.4
vs. 29.3±0.8mg/dl; P=0.001, APOA1: 120.9±1.6 vs. 107.7±1.5mg/dl; P=0.001, and APOB: 95.2±3.4
vs. 74.4±2.6mg/dl; P=0.001). The differences of lipid and lipoprotein profile between pre- and
post-menopause CSX was not significant. In conclusion, plasma lipid disorders play important
roles in the development of CSX. Changes that occur in the lipid profile after menopause are
not associated with increased CSX