Solvent free synthesis of alkyl 2-(dialkylamino)-4 phenylthiazole-5- carboxylates derivatives and in vitro antimycobacterial activity of these compounds against Mycobacterium smegmatis

The reaction between secondary amines, benzoyl isothiocyanate, and dialkyl acetylene dicarboxylates (dialkyl but-
2-ynedioates) in the presence of silica gel (SiO2) led to alkyl 2-(dialkylamino)-4-phenylthiazole-5-carboxylates in
fairly high yields. The structures of these products were confirmed by their IR, 1H and13CNMR, and mass spectra
determination. All compounds have been screened for antimicrobial activity against Mycobacterium smegmatis by
broth dilution and agar well diffusion methods. All the synthesized derivatives exhibited remarkable activity against
this bacterium.