Premarital Screening of Beta Thalassemia in Urmia County of Northwest Iran During 2014: A Short Report

Beta thalassemia is one of the most prevalent genetic disorders in Iran. Nowadays the
premarital screening program for beta thalassemia has brought the highest concern and attention in our country to
prevent any child birth affected by the major thalassemia.Thalassemia major leads to serious medical, social, and
economic problems for patients and their families, and patient’s care represents a considerable financial burden for the
public health budget. The aim of this study was to evaluate the premarital screening program for beta thalassemia in
Eghbal Health Center of Urmia during 2014.
Materials and Methods: In this cross-sectional study 2341 volunteers (2167 men and 174 women) participated for
routine premarital screening in Eghbal Health Center of Urmia. All men’s volunteers and those men’s wives with low
blood indices [MCH (mean cell hemoglobin) <27 pg, MCV (mean red cell volume) <80 fl) and HbA2>%3.5], were
included. Hematologic parameters were measured by automated cell counter Sysmex KX-21N. Data were analyzed
using one-way ANOVA and post Hoc Tukey test.
Results: From 2341 subjects, 174 men had MCV<80 fl or MCH<27 pg, so the hematologic indices of their spouses
(174 females) were also assessed. 58 women had MCV<80 fl or MCH<27 pg. Among these 58 couples (116 subjects),
98 persons (84 women and 14 men) with iron deficiency anemia, 9 participants (7 women and 2 men) with beta
thalassemia and 9 participants (2 women and 7 men) with alpha thalassemia were diagnosed. The frequency of alpha
thalassemia and beta thalassemia carriers among men referred to Eghbal Health Center of Urmia was 0.32% and
0.09%, respectively. In beta thalassemia group, HbA2 level showed a significant increase in comparison with
thalassemia major and iron deficiency anemia groups (p=0.001). MCH and MCV levels in beta thalassemia patients
were significantly lower than in two other groups (p=0.001).
Conclusion: Our findings showed that in 2014, the frequency of thalassemia carriers among men referred to the
Eghbal Health Center of Urmia is low. However, implementation of thalassemia screening program in the city can
effectively prevent the birth of children with thalassemia and prevent unwanted medical costs