Fathi Azarbaijani, A and Panahi Azar, V and Sajed Amin, S and Jouyban, A.G and Asadpour Zeynali, K (2016) Co-solubilization of Lamotrigine by Complexation and Micellization in Binary Solvent Mixtures. chemical engineering research and design, 105. pp. 64-70.
251.pdf
Download (1MB) | Preview
Abstract
The present work was carried out with the purpose of evaluating the effect of -cyclodextrin
(-CD), sodium lauryl sulfate (SLS) and polyethylene glycol 200 (PEG 200) on the solubilization
of lamotrigine by means of phase-solublility studies and solubility prediction using JouybanAcree model.
The experimental solubility values of various mixtures were fitted to the equation and
fitting accuracy of solubility data to this model was evaluated. A quantitative relationship
between the solubilizing agents was assessed and the predictive accuracy of the JouybanAcree model and its applicability assuring reliable prediction of the model in binary systems
was studied. The significance of the simultaneous presence of SLS and -CD on lamotrigine
solubility was studied in binary solvent mixture.
© 2015 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Solubility Cosolvency Complexing agents Micelization Jouyban-Acree model |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 20 Oct 2018 09:07 |
| Last Modified: | 13 Feb 2019 08:09 |
| URI: | https://eprints.umsu.ac.ir/id/eprint/5250 |
Actions (login required)
- View Item