The effect of Crocus sativus (saffron) on the severity of premenstrual syndrome

Pirdadeh Beiranvand, S and Behboodi Moghadam, Z and Nabiollah Beiranvand, S and Birjandi, M and Rezaei, E and Azhari, S and Beiranvand, S and Nazar Salehnia, A (2015) The effect of Crocus sativus (saffron) on the severity of premenstrual syndrome. European Journal of Integrative Medicine. pp. 1-7.

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Abstract

Introduction: Premenstrual syndrome is one of the most common problems for women during their reproductive age and has wider impacts affecting their family and their work. Herbal products are a suggested way of treating the syndrome. This research was carried out to identify whether saffron could have an effect on the severity of premenstrual syndrome among female students. Methods: This randomized triple-blind controlled clinical trial was carried out with 78 students aged 18– 35 years residing in university accommodation. The intervention group received capsules containing 30 mg of dried extract of saffron stigma once a day and the control group received placebo capsules for two menstrual cycles. The data gathering instrument consisted of questionnaire, the DASS21 scale, and premenstrual symptoms assessment form. Results: At the beginning of the study, the two groups did not differ significantly in terms of their mean severity of PMS (P = 0.81). At the end of the study, the changes of the mean severity of PMS were significantly different compared with those in the beginning: P < 0.001 for the intervention group, and p = 0.04 for the control group. In total, the two groups had significant differences in terms of changes in the mean severity of PMS over time (P < 0.001). Conclusion: The results of this study suggest that saffron reduces the severity of PMS symptoms, but in

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