The Extract of Lycium depressum Stocks Enhances Wound Healing in Streptozotocin-Induced Diabetic Rats

In diabetes, impaired wound healing and other tissue abnormalities are considered major concerns. The aim of the present
study was to assess the wound-healing activity of methanolic extracts of the extract of Lycium depressum leaves. A total of 60
healthy male Wistar diabetic rats weighing approximately 160 to 180 g and 7 weeks of age were randomized into 10 groups
for incision and excision wound models: sham surgery group (SHAM), including creation of wounds and no treatment; base
formulation group (FG) with creation of wounds and application of base formulation ointment; treatment group 1 (TG1)
with 1 g of powder extract of the plant material in ointment; treatment group 2 (TG2) with 2 g; and treatment group 4
(TG3) with 4 g of powder extract of the plant material in ointment. A wound was induced by an excision- and incisionbased
wound model in male rats. The mature green leaves of L depressum were collected and authenticated. Extractions
of dried leaves were carried out. For wound-healing activity, the extracts were applied topically in the form of ointment
and compared with control groups. The healing of the wound was assessed based on excision, incision, hydroxyproline
estimation, and biomechanical and biochemical studies. The extract of L depressum leaves enhanced wound contraction,
decreased epithelialization time, increased hydroxyproline content, and improved mechanical indices and histological
characteristics in treatment groups compared with SHAM and FG (P < .05). These findings permit the conclusion the
extract of L depressum benefits parameters of wound healing in a diabetes induced model