ASSOCIATION OF TCF7L2 RS11196205(C/G) AND CAPN10 RS3792267 (G/A) POLYMORPHISMS WITH TYPE II DIABETES IN ARAB POPULATION OF KHUZESTAN PROVINCE

Gravand, A and Pourmehdi Boroujeni, M and Foroughmand, A.M (2018) ASSOCIATION OF TCF7L2 RS11196205(C/G) AND CAPN10 RS3792267 (G/A) POLYMORPHISMS WITH TYPE II DIABETES IN ARAB POPULATION OF KHUZESTAN PROVINCE. The Journal of Urmia University of Medical Sciences, 29 (8). pp. 603-613.

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Abstract

Type II diabetes is a multifactorial and heterogenic disease that is characterized by a defect in the production or function of insulin. In recent years, through Genome-wide association studies (GWAS) has been shown the association of several genes with Type II diabetes. The aim of this study was to investigate the relationship of polymorphisms TCF7L2 rs11196205 and CAPN10 rs3792267 with type II diabetes in the Arab population of Khuzestan province. Materials & Methods: A case-control study was performed using 98 T2DM patients and 96 Controls. Genotyping for rs11196205 was done by TETRA-Primer ARMS-PCR and for rs3792267 was done by PCR-RFLP Technique. Results: In examining rs11196205 based on the genotype GG, results for CG genotype were, OR = 1.29, 95%CI = (0.58–2.86), P -value = 0.54 and for genotype CC were, OR = 2.62, 95%CI = (1.06–6.44), P -value = 0.037. Also, the frequencies of C and G alleles in p atients with diabetes were 60.71% and 39.28%, resp ectively, and in the healthy subjects was 50% for each of the alleles (OR = 1.55, 95%CI = (1.03–2.31), P -value = 0.04). There was no significant association with type II diabetes for rs3792267 in the studied population. Conclusion: Our results for TCF7L2 rs11196205 polymorphism showed that CC genotype and C allele increase the risk of developing type II diabetes in the Arab population of Khuzestan province

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