Saboory, E and Roshan Milani, SH and Ghadimkhani, M (2019) Effect of early‐life inflammation and magnesium sulfate on hyperthermia‐induced seizures in infant rats: Susceptibility to pentylenetetrazol‐induced seizures later in life. Developmental Psychobiology, 61. pp. 96-106.
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Abstract
This study investigated the effect of inflammation and MgSO4 pretreatment on behaviors
caused by hyperthermia (HT) and the effect of these interventions on PTZinduced
seizure a week later. In this experimental study, rat pups experienced
inflammation on postnatal day 10 (P10). On P18–19, the pups received either saline
or MgSO4 then subjected to hyperthermia. On P25–26, PTZ‐induced seizure was initiated
in the rats. Neonatal inflammation increased the susceptibility to HT‐induced
seizure. Inflammation and HT increased the susceptibility to PTZ‐induced seizure.
Pretreatment with MgSO4 before hyperthermia decreased the susceptibility to both
HT‐ and PTZ‐induced seizure. Furthermore, calcium and magnesium blood levels significantly
decreased compared to control rats. It can be concluded that neonatal inflammation
potentiates while pretreatment with MgSO4 attenuates HT‐induced
seizures. Also, neonatal inflammation and HT potentiate PTZ‐induced seizure initiated
one week later.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | hyperthermia, inflammation, magnesium, neonatal, rat, seizure |
| Subjects: | R Medicine > R Medicine (General) |
| Depositing User: | Unnamed user with email gholipour.s@umsu.ac.ir |
| Date Deposited: | 03 Mar 2019 04:55 |
| Last Modified: | 30 Jun 2019 03:54 |
| URI: | https://eprints.umsu.ac.ir/id/eprint/5437 |
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