Tropisetron ameliorates oxidative stress in type-1 diabetic experimental rats

In this study, we evaluated the effect of tropisetron on the oxidative biomarkers in the plasma of type 1 diabetes mellitus (DM). Twentyone
male Wistar rats were randomly divided into three experimental groups (n =7): control, diabetic and diabetic + tropisetron. Diabetes
type 1 was induced by streptozotocin (STZ) (50 mg/kg; i.p). Tropisetron (3 mg/kg; i.p) as a 5-HT3 antagonist was given once daily for
2 weeks. At the end of experiment animals were euthanized and blood samples were collected for further analysis including superoxide
dismutase (SOD), glutathione peroxidase (GPx) activities and malondialdehyde (MDA), total antioxidant capacity (TAC) levels. We
found that tropisetron attenuated MDA levels and increased SOD, GPx and TAC contents in the plasma of diabetic rats. Our findings
indicate that tropisetron improved oxidative stress in the plasma of STZ induced-diabetic rats