Relationship between low maternal vitamin D status and the risk of severe preeclampsia: A case control study

Pashapour, S and Behroozi Lak, T and Golmohammad Lou, S and Ghasemnejad Berenji, H and Ghasemnejad Berenji, M and Sadeghpour, S (2019) Relationship between low maternal vitamin D status and the risk of severe preeclampsia: A case control study. Pregnancy Hypertension, 15. pp. 161-165.

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Abstract

Low maternal vitamin D status has been associated with several adverse outcomes during pregnancy. The aim of the study was to evaluate the vitamin D levels in preeclamptic and healthy pregnant women and the role of vitamin D deficiency in the etiology of preeclampsia. Methods: In this case-control study, 80 preeclamptic women and 80 healthy pregnant women were selected from Motahari hospital in Urmia, Iran. 2 ml of venous blood sample was collected from each pregnant woman and the serum 25-OH-D level was measured by Enzyme-Linked Immunosorbent Assay (ELISA) and reported in nanograms per milliliter. levels of 25-OH-D less than 10 ng mL−1, between 10 ng mL−1 and 29 ng mL−1 and more than 30 ng mL−1, were considered as deficient, insufficient and normal 25-OH-D concentrations, respectively. Results were analyzed by independent t-test, Mann-Whitney U test, and logistic regression. Results: Preeclamptic women (n=80) were noted to have decreased total 25-OH-D levels relative to healthy control women (n=80; P=0.01). This difference in total 25-OH-D remained significant after control for potential confounders [odds ratio (OR)=4.79, confidence interval (CI)=1.45–9.87, P=0.01]. Conclusion: These results showed that vitamin D deficiency has a statistically significant relationship with preeclampsia and support the hypothesis that vitamin D deficiency may be a risk factor for preeclampsia

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