Comparison of myocardial apoptosis in 21 and 90 days after birth in pups induced by maternal long term ethanol consumption

Shirpoor, A.R and Naderi, R and Gaderi, R and Nezami Majd, F (2019) Comparison of myocardial apoptosis in 21 and 90 days after birth in pups induced by maternal long term ethanol consumption. International Journal of Research in Applied and Basic Medical Sciences, 5 (1). pp. 30-35.

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Abstract

This study was designed to assess and the cardiac apoptosis after the prenatal and early postnatal ethanol treatment in pups. Materials and Methods: Pregnant Wistar rats treated with ethanol 4.5g/kg BW once per day from the seventh day of gestation (GD7) throughout lactation. Apoptotic cells, body wight, heart weight and their association on postnatal day 21 (PN-21) and postnatal day 90 (PN-90) was evaluated in male pups. Results: The results showed that maternal ethanol consumption increased apoptotic cells, decreased heart weight, body weight, and HW/BW after 21 and 90 days of birth compared with the controls. It has found more apoptotic cells in 90 days after births compared with 21 days of age. Conclusions: our findings revealed that maternal ethanol intake in pups decreased HW/BW ratio in part through apoptosis, which is more predominant in 90 days of age

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