Evaluation of Malondialdehyde Levels and Total Antioxidant Capacity in Patients with Hyperthyroidism

Oxidative stress is involved in the pathogenesis of many diseases. Oxidative stress and antioxidant imbalance
conditions play a major role in the incidence and development of hyperthyroidism. The aim of this study is to evaluate malondialdehyde
(MDA) levels as lipid peroxidation index and total antioxidant capacity (TAC) in hyperthyroid patients compared to control group.
Materials and Methods: A case-control study was performed on 35 women with hyperthyroidism and 35 healthy women as control
group. Measurement of MDA serum levels was performed by Human Malondealdhyde (MDA) ELIZA KIT from Bioassay Chinese
Company by ELIZA method, and serum level measurement was performed by GmbH Zellbio from Zellbio German Company using
the ELIZA method.
Results: The serum MDA concentration in patients with hyperthyroidism (20.59 ± 2.50 nmol/mL) significantly increased (P = 0.001)
compared to the control group (9.94 ± 2.12 nmol/mL), while the serum TAC concentration in the hyperthyroid group (0.769 ± 0.145)
significantly decreased (P = 0.001) compared to the control group (1.63 ± 0.286).
Conclusion: In this study, total antioxidant capacity in patients with hyperthyroidism was reduced compared to control group, and
levels of malondialdehyde increased. These findings indicate that the thyroid gland plays an important role in the production of
oxidative stress in disease conditions. Therefore, it is recommended that thyroid hormone disorders and oxidative stress be used in the
therapeutic strategies of hyperthyroidism